A new holographic microscope to see through the skull

Researchers developed a new type of holographic microscope. It can see through the intact skull, and is capable of high-resolution 3D imaging of the neural network within a living mouse brain without removing the skull, and allows for the observation of tissues to a greater depth than ever before.

The new microscope succeeded in obtaining a high-resolution image of the mouse brain's neural network under the skull. This was all achieved in the visible wavelength without removing the mouse skull and without requiring a fluorescent label.

It is expected that our present finding will greatly contribute to the development of biomedical interdisciplinary research including neuroscience and the industry of precision metrology.