Nanoparticles could save lives by stopping Internal bleeding

Internal bleeding still comes with a very high risk of fatality. One new "drug" uses magnetically-driven nanoparticles to both stop bleeding and reduce blood loss.

Scientists  are hoping to improve outcomes for internal bleeding patients using nanoparticles. They suggests that by using magnetically-driven nanoparticles containing the clotting promoter thrombin, they can

effectively stop internal bleeding.

This research, published in the journal Scientific Reports, describes how a drug created using these nanoparticles can be injected intravenously, directly to the site of injury. When injected into a simulated blood vessel, this drug accelerated local clot formation by 6.5 times and reduced blood loss by 15 times which is extraordinarily effective.

These miraculous-seeming particles contain a core of thrombin, an enzyme that triggers blood clot formation. Researchers then wrap the enzyme in a porous matrix of magnetite, the second main ingredient. This allows the nanoparticles in the body to be moved very precisely with an external magnetic field and localize them to the site of injury.

Synthesizing these nanoparticles is not easy, It is important to keep their size down to 200 nanometers; otherwise they will not be suitable for injection. In addition, mild synthesis conditions are required so that the thrombin molecule does not break down and lose its activity completely. Finally, we could only use bio-compatible components. Further testing and investment will certainly be necessary.

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